Title: pc4covid19/pharmacodynamics-submodel: Version 0.3.0

Type Software Yafei Wang (2022): pc4covid19/pharmacodynamics-submodel: Version 0.3.0. Zenodo. Software. https://zenodo.org/record/6017183

Author: Yafei Wang (Indiana University Bloomington) ;

Links

• Item record in Zenodo
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Summary

Add model of cell fusion process in this version of release: The conditions for cell fusion: population of intracellular assembled virion is greater than a threshold distance of two potential fused cells is smaller than a threshold frequency of cell fusion is smaller than a threshold (in case a cell can become fused many times) randomly sampled probability is smaller than the probability of cell fusion (which is positively corrected with the population of intracellular assembled virion) If cell fusion happened, then: new fused cell's position is the mean of two cells new fused cell's volume will be updated population of ACE2 as well as intracellular virion will be updated new fused cell's intracellular virion can replicate faster (with increasing uncoating RNA and protein synthesis rates). In addition, fused cell also has larger viral tolerant capability (with increasing half of maximum apoptosis rate). The effect of drug on cell fusion and virial spread: drug only inhibits cell fusion (through reduce the probability of cell fusion) drug only inhibits endocytosis and exocytosis drug inhibits both cell fusion, and endocytosis, exocytosis

More information

• DOI: 10.5281/zenodo.6017183

Dates

• Publication date: 2022
• Issued: February 09, 2022

Rights

• info:eu-repo/semantics/openAccess Open Access

Format

electronic resource

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