Title: COVID19 pharmacodynamics response tissue simulator
Type Software Yafei Wang (2020): COVID19 pharmacodynamics response tissue simulator. Zenodo. Software. https://zenodo.org/record/3988570
Links
- Item record in Zenodo
- Digital object URL
Summary
This release matches with version used in the paper Maraviroc inhibits SARS-CoV-2 multiplication and s-protein mediated cell fusion in cell culture
In this release:
Use intracellular drug concentration in calculating drug effect Update receptor dynamics, replication dynamics, export rate parameters and EC_50 to match with experimental data Add negative feedback for ACE2 binding, endocytosis process Pick up 3000 cells randomly binded with virion, rather than internalization in the beginning Use Dirichlet nodes for all voxels in the simulationMore information
- DOI: 10.5281/zenodo.3988570
Dates
- Publication date: 2020
- Issued: August 17, 2020
Rights
- info:eu-repo/semantics/openAccess Open Access
Format
electronic resource
Relateditems
| Description | Item type | Relationship | Uri |
|---|---|---|---|
| IsSupplementTo | https://github.com/pc4covid19/pharmacodynamics-submodel/tree/0.2.0 | ||
| IsVersionOf | https://doi.org/10.5281/zenodo.3967412 | ||
| IsPartOf | https://zenodo.org/communities/covid-19 | ||
| IsPartOf | https://zenodo.org/communities/zenodo |