Title: Genetic Variability at the ADP Ribose Binding Site of SARS-CoV-2 Macrodomain and Predicting Its Effects on ADP Ribose Binding

Type Other Yazdani, Setayesh, Nicola, De Maio, Schapira, Matthieu (2020): Genetic Variability at the ADP Ribose Binding Site of SARS-CoV-2 Macrodomain and Predicting Its Effects on ADP Ribose Binding. Zenodo. Other. https://zenodo.org/record/3956555

Authors: Yazdani, Setayesh (Structural Genomics Consortium) ; Nicola, De Maio (European Bioinformatics Institute) ; Schapira, Matthieu (Structural Genomics Consortium) ;

Links

• Item record in Zenodo
• Digital object URL

Summary

In this report, I will explain how we identified the ADP ribose (ADPr) binding site of Mac1 and its druggability measure, and list the residues lining that site. Then I will present diversity dendrograms of UniProt entries of Alpha- and Betacoronavirus genera while focusing on Mac1 ADPr binding site. Following that, I will show the predicted effects on ADPr binding to Mac1 due to changes in Gibbs free energy of ligand binding as a result of the non-synonymous variants that Nicola De Maio, our collaborator from European Bioinformatics Institute, has identified at ADPr binding site.

More information

• DOI: 10.5281/zenodo.3956555

Dates

• Publication date: 2020
• Issued: July 22, 2020

Rights

• https://creativecommons.org/licenses/by/4.0/legalcode Creative Commons Attribution 4.0 International
• info:eu-repo/semantics/openAccess Open Access

Format

electronic resource

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