Title: Case report: a post-traumatic Neuro-COVID-19. Casuality or causality?

Type Other Cortassa Giorgio Mario, Bottone Stefania, Saia Valentina, Grillo Giovanna, Bertolino Monica, Tassinari Tiziana, Mangerini R, Tedone E (2020): Case report: a post-traumatic Neuro-COVID-19. Casuality or causality?. Zenodo. Other. https://zenodo.org/record/3902305

Authors: Cortassa Giorgio Mario ; Bottone Stefania ; Saia Valentina ; Grillo Giovanna ; Bertolino Monica ; Tassinari Tiziana ; Mangerini R ; Tedone E ;

Links

• Item record in Zenodo
• Digital object URL

Summary

We describe the case of a 77 years old man with relevant oncologic comorbidities but in good general conditions who developed a rapidly deteriorating neurologic status up to a refractory coma just after a relatively minor accidental head and chest trauma. Emergency CT imaging of the brain and chest was not significant but DWI demonstrated a diffuse brain subcortical micro-ischemic pattern. EEG showed diffuse slow rhythm and cerebrospinal fluid (CSF) analysis revealed an inflammatory pattern with elevated proteinorrachia. The RT-PCR on pharyngeal swab was positive for SARS-CoV2 and generic Coronavirus antigens were found in CSF. In the following days, the patient developed a cytokine storm, a typical COVID-19 pneumonia and died 13 days after admission. In the specific macro-emergency context autopsy was not feasible, though laboratory findings support the pathogenetic role of Coronavirus in central nervous system damage. We do not know if the strict chronologic succession suggests a possible role of the head trauma in the development of the neurologic condition of this COVID-19 patient. We believe this report add to the knowledge about the presence of a Coronavirus in CSF.

More information

• DOI: 10.5281/zenodo.3902305
• Language: en

Subjects

• COVID-19, head trauma, neurologic presentation, DWI imaging, Coronavirus in liquor

Dates

• Publication date: 2020
• Issued: June 20, 2020

Rights

• https://creativecommons.org/licenses/by/4.0/legalcode Creative Commons Attribution 4.0 International
• info:eu-repo/semantics/openAccess Open Access

Format

electronic resource

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