Title: Epidemiology, risk factors and clinical course of SARS-CoV-2 infected patients in a Swiss university hospital: an observational retrospective study

Type Dataset Jean Regina, Matthaios Papadimitriou-Olivgeris, Raphaël Burger, Paraskevas Filippidis, Jonathan Tschopp1, Florian Desgranges, Benjamin Viala, Eleftheria Kampouri, Laurence Rochat, David Haefliger, Mehdi Belkoniene, Carlos Fidalgo, Antonios Kritikos, Katia Jaton, Laurence Senn, Pierre-Alexandre Bart, Jean-Luc Pagani, Oriol Manuel, Loïc Lhopitallier (2020): Epidemiology, risk factors and clinical course of SARS-CoV-2 infected patients in a Swiss university hospital: an observational retrospective study. Zenodo. Dataset. https://zenodo.org/record/3799740

Authors: Jean Regina (Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland) ; Matthaios Papadimitriou-Olivgeris (Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland) ; Raphaël Burger (Service of Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland) ; Paraskevas Filippidis (Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland) ; Jonathan Tschopp1 (Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland) ; Florian Desgranges (Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland) ; Benjamin Viala (Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland) ; Eleftheria Kampouri (Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland) ; Laurence Rochat (Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland) ; David Haefliger (Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland) ; Mehdi Belkoniene (Service of Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland) ; Carlos Fidalgo (Service of Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland) ; Antonios Kritikos (Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland) ; Katia Jaton (Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland) ; Laurence Senn (Service of Hospital Preventive Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland) ; Pierre-Alexandre Bart (Service of Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland) ; Jean-Luc Pagani (Service of Intensive Care, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland) ; Oriol Manuel (Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland) ; Loïc Lhopitallier (Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland) ;

Links

• Item record in Zenodo
• Digital object URL

Summary

This is the dataset of the study called "Epidemiology, risk factors and clinical course of SARS-CoV-2 infected patients in a Swiss university hospital: an observational retrospective study".  Abstract: 

Background Coronavirus disease 2019 (COVID-19) is now a global pandemic with Europe and the USA at its epicenter. Little is known about risk factors for progression to severe disease in Europe. This study aims to describe the epidemiology of COVID-19 patients in a Swiss university hospital.

Methods This retrospective observational study included all adult patients hospitalized with a laboratory confirmed SARS-CoV-2 infection from March 1 to March 25, 2020. We extracted data from electronic health records. The primary outcome was the need to mechanical ventilation at day 14.  We used multivariate logistic regression to identify risk factors for mechanical ventilation. Follow-up was of at least 14 days.      Results 200 patients were included, of whom 37 (18·5%) needed mechanical ventilation at 14 days. The median time from symptoms onset to mechanical ventilation was 9·5 days (IQR 7.00, 12.75). Multivariable regression showed increased odds of mechanical ventilation in males (3.26, 1.21-9.8; p=0.025), in patients who presented with a qSOFA score ≥2 (6.02, 2.09-18.82; p=0.001), with bilateral infiltrate (5.75, 1.91-21.06; p=0.004) or with a CRP of 40 mg/l or greater (4.73, 1.51-18.58; p=0.013).     Conclusions This study gives some insight in the epidemiology and clinical course of patients admitted in a European tertiary hospital with SARS-CoV-2 infection. Male sex, high qSOFA score, CRP of 40 mg/l or greater and a bilateral radiological infiltrate could help clinicians identify patients at high risk for mechanical ventilation.

More information

• DOI: 10.5281/zenodo.3799740

Subjects

• COVID-19, SARS-CoV-2, Switzerland, Mechanical Ventilation

Dates

• Publication date: 2020
• Issued: May 06, 2020

Rights

• https://creativecommons.org/licenses/by/4.0/legalcode Creative Commons Attribution 4.0 International
• info:eu-repo/semantics/openAccess Open Access

Format

electronic resource

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