Title: Selectomic and Evolvability Analyses of the Highly Pathogenic Betacoronaviruses SARS-CoV-2, SARS-CoV, and MERS-CoV

Type Dataset May, Meghan (2020): Selectomic and Evolvability Analyses of the Highly Pathogenic Betacoronaviruses SARS-CoV-2, SARS-CoV, and MERS-CoV. Zenodo. Dataset. https://zenodo.org/record/3756937

Author: May, Meghan (University of New England) ;

Links

• Item record in Zenodo
• Digital object URL

Summary

SARS-CoV-2, the causative agent of COVID-19, is widespread in several countries around the world following its late 2019 emergence in humans. We determined the SARS-CoV-2 selectome by calculating rates of pervasive and episodic diversifying selection for every amino acid coding position in the SARS-CoV-2 genome. To provide context for evolutionary dynamics of a highly pathogenic betacoronavirus following a zoonotic spillover into human hosts, we also determined the selectomes of SARS-CoV and MERS-CoV, and performed evolvability calculations for SARS-CoV-2 based on SARS-CoV.  These findings provide a comprehensive view of zoonotic, highly pathogenic betacoronavirus evolutionary dynamics that can be directly applied to diagnostic assay and vaccine design for SARS-CoV-2.

More information

• DOI: 10.5281/zenodo.3756937

Subjects

• COVID-19, SARS-CoV-2, Coronavirus, SARS-CoV, MERS-CoV, Evolvability, Diversifying Selection, Diagnostic Test, Vaccine, Emerging Diseases

Dates

• Publication date: 2020
• Issued: April 18, 2020

Rights

• https://creativecommons.org/licenses/by/4.0/legalcode Creative Commons Attribution 4.0 International
• info:eu-repo/semantics/openAccess Open Access

Format

electronic resource

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